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Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.

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Title: Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.
Authors: Kaiser RA; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Midwest Fetal Care Center, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States of America., Carlson DF; Recombinetics, Inc., St. Paul, Minnesota, United States of America., Allen KL; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Webster DA; Recombinetics, Inc., St. Paul, Minnesota, United States of America., VanLith CJ; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Nicolas CT; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Faculty of Medicine, University of Barcelona, Barcelona, Spain., Hillin LG; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Yu Y; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Kaiser CW; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Wahoff WR; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America., Hickey RD; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America., Watson AL; Recombinetics, Inc., St. Paul, Minnesota, United States of America., Winn SR; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America., Thöny B; Department of Pediatrics, University of Zurich, Zurich, Switzerland., Kern DR; Recombinetics, Inc., St. Paul, Minnesota, United States of America., Harding CO; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America., Lillegard JB; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Midwest Fetal Care Center, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States of America.; Pediatric Surgical Associates, Minneapolis, Minnesota, United States of America.
Source: PloS one [PLoS One] 2021 Jan 25; Vol. 16 (1), pp. e0245831. Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.
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  Data: <searchLink fieldCode="AU" term="%22Kaiser+RA%22">Kaiser RA</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Midwest Fetal Care Center, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Carlson+DF%22">Carlson DF</searchLink>; Recombinetics, Inc., St. Paul, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Allen+KL%22">Allen KL</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Webster+DA%22">Webster DA</searchLink>; Recombinetics, Inc., St. Paul, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22VanLith+CJ%22">VanLith CJ</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Nicolas+CT%22">Nicolas CT</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Faculty of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hillin+LG%22">Hillin LG</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Kaiser+CW%22">Kaiser CW</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Wahoff+WR%22">Wahoff WR</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Hickey+RD%22">Hickey RD</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Watson+AL%22">Watson AL</searchLink>; Recombinetics, Inc., St. Paul, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Winn+SR%22">Winn SR</searchLink>; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America.<br /><searchLink fieldCode="AU" term="%22Thöny+B%22">Thöny B</searchLink>; Department of Pediatrics, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kern+DR%22">Kern DR</searchLink>; Recombinetics, Inc., St. Paul, Minnesota, United States of America.<br /><searchLink fieldCode="AU" term="%22Harding+CO%22">Harding CO</searchLink>; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States of America.<br /><searchLink fieldCode="AU" term="%22Lillegard+JB%22">Lillegard JB</searchLink>; Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America.; Midwest Fetal Care Center, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States of America.; Pediatric Surgical Associates, Minneapolis, Minnesota, United States of America.
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