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Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study.

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Title: Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study.
Authors: van Groenendael R; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Beunders R; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Hemelaar P; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands., Hofland J; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Morshuis WJ; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., van der Hoeven JG; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Gerretsen J; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands., Wensvoort G; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Kooistra EJ; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Claassen WJ; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Waanders D; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Lamberts MGA; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Buijsse LSE; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Kox M; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., van Eijk LT; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands., Pickkers P; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.
Source: Critical care medicine [Crit Care Med] 2021 May 01; Vol. 49 (5), pp. 790-803.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study.
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  Data: <searchLink fieldCode="AU" term="%22van+Groenendael+R%22">van Groenendael R</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Beunders+R%22">Beunders R</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hemelaar+P%22">Hemelaar P</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hofland+J%22">Hofland J</searchLink>; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Morshuis+WJ%22">Morshuis WJ</searchLink>; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Hoeven+JG%22">van der Hoeven JG</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gerretsen+J%22">Gerretsen J</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wensvoort+G%22">Wensvoort G</searchLink>; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kooistra+EJ%22">Kooistra EJ</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Claassen+WJ%22">Claassen WJ</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Waanders+D%22">Waanders D</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lamberts+MGA%22">Lamberts MGA</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Buijsse+LSE%22">Buijsse LSE</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kox+M%22">Kox M</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Eijk+LT%22">van Eijk LT</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pickkers+P%22">Pickkers P</searchLink>; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.; Exponential Biotherapies, Inc. (EBI), The Hague, The Netherlands.
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