Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.
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| Title: | Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. |
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| Authors: | Nabais MF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Laws SM; School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia., Lin T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Vallerga CL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; Department of Internal Medicine, Erasmus MC, University Medical Center, 3015GD, Rotterdam, The Netherlands., Armstrong NJ; Murdoch University, 90 South St, Murdoch, WA, 6150, Australia., Blair IP; Australian Centre for Precision Health, University of South Australia Cancer Research Institute, School of Health Sciences, University of South Australia, Adelaide, SA, 5001, Australia., Kwok JB; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.; Neuroscience Research Australia Institute, Randwick, NSW, 2031, Australia., Mellick GD; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2031, Australia.; Neuropsychiatric Institute, The Prince of Wales Hospital, UNSW, Randwick, NSW, 2031, Australia., Wallace L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Zwamborn RAJ; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Hop PJ; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Lunnon K; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Pishva E; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Roubroeks JAY; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Soininen H; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland., Tsolaki M; 1st Department of Neurology, Memory and Dementia Unit, Aristotle University of Thessaloniki, Thessaloniki, Greece., Mecocci P; Department of Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy., Lovestone S; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK., Kłoszewska I; Medical University of Lodz, Lodz, Poland., Vellas B; INSERM U 558, University of Toulouse, Toulouse, France., Furlong S; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Garton FC; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Henderson RD; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, VIC, 3195, Australia., McCombe PA; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia., Needham M; Fiona Stanley Hospital, Perth, WA, 6150, Australia.; Notre Dame University, Fremantle, WA, 6160, Australia.; Institute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, 6150, Australia., Ngo ST; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia.; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, 4019, Australia.; The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia., Nicholson G; ANZAC Research Institute, Concord Repatriation General Hospital, Sydney, NSW, 2139, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia., Williams KL; Centre for Motor Neuron Disease Research, Macquarie University, Sydney, NSW, 2109, Australia., Anderson TJ; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand., Bentley SR; Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia., Dalrymple-Alford J; New Zealand Brain Research Institute, Christchurch, New Zealand.; School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand., Fowder J; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia., Gratten J; Mater Research, Translational Research Institute, Brisbane, Australia.; Mater Research Institute, The University of Queensland, Brisbane, Australia., Halliday G; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Hickie IB; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Kennedy M; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand., Lewis SJG; Brain and Mind Research Centre, Sydney Medical School, The University of Sydney, Sydney, Australia., Montgomery GW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Pearson J; Department of Pathology, University of Otago, Christchurch, New Zealand., Pitcher TL; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand., Silburn P; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., Zhang F; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Harris SE; Department of Psychology, Lothian Birth Cohorts group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Deary IJ; Department of Psychology, Lothian Birth Cohorts group, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Jones AR; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Shatunov A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Iacoangeli A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., van Rheenen W; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., van den Berg LH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Shaw PJ; SITraN, University of Sheffield, Sheffield, UK., Shaw CE; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK., Morrison KE; Queen's University Belfast, Belfast, Northern Ireland, UK., Al-Chalabi A; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, SE5 9RX, UK.; King's College Hospital, London, SE5 9RS, UK., Veldink JH; Department of Neurology, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Hannon E; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK., Mill J; University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. a.mcrae@uq.edu.au. |
| Corporate Authors: | Australian Imaging Biomarkers and Lifestyle study, Alzheimer’s Disease Neuroimaging Initiative |
| Source: | Genome biology [Genome Biol] 2021 Mar 26; Vol. 22 (1), pp. 90. Date of Electronic Publication: 2021 Mar 26. |
| Publication Type: | Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1474-760X |
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| DOI: | 10.1186/s13059-021-02275-5 |