Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.

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Title: Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.
Authors: Hipp JF; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Knoflach F; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Comley R; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.; AbbVie Inc, North Chicago, IL, USA., Ballard TM; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.; Galwyn (UK) Ltd, Dartmouth, Devon, UK., Honer M; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Trube G; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Gasser R; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Prinssen E; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Wallace TL; CNS Research, Roche Bioscience, Palo Alto, USA.; BlackThorn Therapeutics, 780 Brannan Street, San Francisco, CA, 94103, USA., Rothfuss A; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Knust H; Small Molecule Research, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Lennon-Chrimes S; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK., Derks M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK., Bentley D; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, AL7 1TW, UK., Squassante L; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Nave S; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Nöldeke J; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Wandel C; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland., Thomas AW; Small Molecule Research, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.; Helvetica Capital AG, Zurich, Switzerland., Hernandez MC; Neuroscience & Rare Diseases (NRD) Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland. maria-clemencia.hernandez@roche.com.
Source: Scientific reports [Sci Rep] 2021 Apr 08; Vol. 11 (1), pp. 7700. Date of Electronic Publication: 2021 Apr 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-021-87307-7