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Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.

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Title: Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.
Authors: Tsimberidou AM; The University of Texas MD Anderson Cancer Center, Houston, Texas. atsimber@mdanderson.org p.beer@karustherapeutics.com., Beer PA; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom. atsimber@mdanderson.org p.beer@karustherapeutics.com., Cartwright CA; The University of Texas MD Anderson Cancer Center, Houston, Texas., Haymaker C; The University of Texas MD Anderson Cancer Center, Houston, Texas., Vo HH; The University of Texas MD Anderson Cancer Center, Houston, Texas., Kiany S; The University of Texas MD Anderson Cancer Center, Houston, Texas., Cecil ARL; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Dow J; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Haque K; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Silva FA; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Coe L; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Berryman H; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Bone EA; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Nogueras-Gonzalez GM; The University of Texas MD Anderson Cancer Center, Houston, Texas., Vining D; The University of Texas MD Anderson Cancer Center, Houston, Texas., McElwaine-Johnn H; Karus Therapeutics LTD, Oxfordshire, England, United Kingdom., Wistuba II; The University of Texas MD Anderson Cancer Center, Houston, Texas.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jul 01; Vol. 27 (13), pp. 3584-3594. Date of Electronic Publication: 2021 May 04.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-21-0238