Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics.

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Title: Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics.
Authors: Lam M; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.; Institute of Mental Health, Singapore, Singapore., Chen CY; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Biogen, Inc, Cambridge, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ge T; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Xia Y; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.; Psychiatry Department, SUNY Upstate Medical University, Syracuse, NY, USA., Hill DW; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland, UK.; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Trampush JW; Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Yu J; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA., Knowles E; Tommy Fuss Center for Neuropsychiatric Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Olin Neuropsychic Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA., Davies G; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland, UK.; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Stahl EA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Huckins L; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liewald DC; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway., Melle I; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Christoforou A; Spaulding Rehabilitation Hospital Boston, Charlestown, MA, USA.; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Reinvang I; Department of Psychology, University of Oslo, Oslo, Norway., DeRosse P; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA., Lundervold AJ; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway., Steen VM; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Espeseth T; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Widen E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland., Eriksson JG; Department of General Practice, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Folkhälsan Research Center, Helsinki, Finland., Giegling I; Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany., Konte B; Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany., Hartmann AM; Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany., Roussos P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA., Giakoumaki S; Department of Psychology, University of Crete, Crete, Greece., Burdick KE; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA.; Department of Psychiatry - Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Payton A; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, The University of Manchester, Manchester, UK., Ollier W; Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, UK.; School of Healthcare Sciences, Manchester Metropolitan University, Manchester, United Kingdom., Chiba-Falek O; Division of Translational Brain Sciences, Department of Neurology, Bryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA., Koltai DC; Psychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA., Need AC; William Harvey Research Institute, Queen Mary University of London, London, UK., Cirulli ET; Helix Inc., San Diego, CA, USA., Voineskos AN; Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada., Stefanis NC; 2nd Department of Psychiatry, National and Kapodistrian University of Athens Medical School, University General Hospital 'ATTIKON', Athens, Greece.; University Mental Health Research Institute, Athens, Greece.; Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece., Avramopoulos D; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hatzimanolis A; 2nd Department of Psychiatry, National and Kapodistrian University of Athens Medical School, University General Hospital 'ATTIKON', Athens, Greece.; University Mental Health Research Institute, Athens, Greece.; Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece., Smyrnis N; 2nd Department of Psychiatry, National and Kapodistrian University of Athens Medical School, University General Hospital 'ATTIKON', Athens, Greece.; University Mental Health Research Institute, Athens, Greece., Bilder RM; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Freimer NB; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Cannon TD; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Department of Psychology, Yale University, New Haven, CT, USA., London E; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Poldrack RA; Department of Psychology, Stanford University, Palo Alto, CA, USA., Sabb FW; Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA., Congdon E; UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA., Conley ED; 23andMe, Inc., Mountain View, CA, USA., Scult MA; Weill Cornell Psychiatry at NewYork-Presbyterian, Weill Cornell Medical Center, New York, NY, USA.; Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA., Dickinson D; Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA., Straub RE; Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA., Donohoe G; Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland., Morris D; Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland., Corvin A; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Gill M; Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Hariri AR; Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA., Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA., Pendleton N; Division of Neuroscience and Experimental Psychology/School of Biological Sciences, Faculty of Biology Medicine and Health, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester, UK., Bitsios P; Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, GR, Greece., Rujescu D; Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland., Le Hellard S; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Keller MC; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., Andreassen OA; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Deary IJ; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, Scotland, UK.; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Glahn DC; Tommy Fuss Center for Neuropsychiatric Disease Research, Boston Children's Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Olin Neuropsychic Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA., Huang H; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Liu C; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China.; Psychiatry Department, SUNY Upstate Medical University, Syracuse, NY, USA., Malhotra AK; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA., Lencz T; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA. tlencz@northwell.edu.; Institute for Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA. tlencz@northwell.edu.; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. tlencz@northwell.edu.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2021 Sep; Vol. 46 (10), pp. 1788-1801. Date of Electronic Publication: 2021 May 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1740-634X
DOI:10.1038/s41386-021-01023-4