Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney.

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Title: Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney.
Authors: Stehle D; Interfakultäres Institut für Biochemie (IFIB), University of Tübingen, Tübingen, Germany., Xu MZ; Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Schomber T; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany., Hahn MG; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany., Schweda F; Institut für Physiologie, Universität Regensburg, Regensburg, Germany., Feil S; Interfakultäres Institut für Biochemie (IFIB), University of Tübingen, Tübingen, Germany., Kraehling JR; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany., Eitner F; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany.; Division of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany., Patzak A; Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Sandner P; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany.; Institute of Pharmacology, Hannover Medical School, Hannover, Germany., Feil R; Interfakultäres Institut für Biochemie (IFIB), University of Tübingen, Tübingen, Germany., Bénardeau A; Bayer AG, Cardiovascular Research, Pharma Research Center, Wuppertal, Germany.; Novo Nordisk A/S, Cardio-Renal Biology, Måløv, Denmark.
Source: British journal of pharmacology [Br J Pharmacol] 2022 Jun; Vol. 179 (11), pp. 2476-2489. Date of Electronic Publication: 2021 Jul 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1476-5381
DOI:10.1111/bph.15586