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Technological readiness and implementation of genomic-driven precision medicine for complex diseases.

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Title: Technological readiness and implementation of genomic-driven precision medicine for complex diseases.
Authors: Franks PW; From the, Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Melén E; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Friedman M; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Sundström J; Department of Cardiology, Akademiska Sjukhuset, Uppsala, Sweden.; George Institute for Global Health, Camperdown, NSW, Australia.; Medical Sciences, Uppsala University, Uppsala, Sweden., Kockum I; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Klareskog L; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Rheumatology, Karolinska Institutet, Stockholm, Sweden., Almqvist C; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Bergen SE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Czene K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hall P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Oncology, Södersjukhuset, Stockholm, Sweden., Johnell K; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Malarstig A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Pfizer, Worldwide Research and Development, Stockholm, Sweden., Catrina A; Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Hagström H; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Division of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden., Benson M; Department of Pediatrics, Linkopings Universitet, Linkoping, Sweden.; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden., Gustav Smith J; Department of Cardiology and Wallenberg Center for Molecular Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and Sahlgrenska University Hospital, Gothenburg, Sweden., Gomez MF; From the, Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden., Orho-Melander M; From the, Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malmö, Sweden., Jacobsson B; Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Genetics and Bioinformatics, Oslo, Norway.; Department of Obstetrics and Gynecology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden., Halfvarson J; School of Medical Sciences, Örebro University, Örebro, Sweden., Repsilber D; Functional Bioinformatics, Örebro University, Örebro, Sweden., Oresic M; School of Medical Sciences, Örebro University, Örebro, Sweden.; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, FI, Finland., Jern C; Department of Clinical Genetics and Genomics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden., Melin B; Department of Radiation Sciences, Oncology, Umeå Universitet, Umeå, Sweden., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, CBAR, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Fall T; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden., Rönnblom L; Department of Medical Sciences, Rheumatology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Wadelius M; Department of Medical Sciences, Clinical Pharmacogenomics & Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Nordmark G; Department of Medical Sciences, Rheumatology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Johansson Å; Institute for Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden., Rosenquist R; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Source: Journal of internal medicine [J Intern Med] 2021 Sep; Vol. 290 (3), pp. 602-620. Date of Electronic Publication: 2021 Jul 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8904841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2796 (Electronic) Linking ISSN: 09546820 NLM ISO Abbreviation: J Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1365-2796
DOI:10.1111/joim.13330