Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
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| Title: | Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma. |
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| Authors: | He C; Department of Developmental Neurobiology, Memphis, TN, USA., Xu K; Center for Applied Bioinformatics, Memphis, TN, USA.; Department of Computational Biology, Memphis, TN, USA., Zhu X; Department of Developmental Neurobiology, Memphis, TN, USA., Dunphy PS; Department of Developmental Neurobiology, Memphis, TN, USA.; Department of Oncology, Memphis, TN, USA., Gudenas B; Department of Developmental Neurobiology, Memphis, TN, USA., Lin W; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Twarog N; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Hover LD; Department of Developmental Neurobiology, Memphis, TN, USA., Kwon CH; Department of Developmental Neurobiology, Memphis, TN, USA., Kasper LH; Department of Developmental Neurobiology, Memphis, TN, USA., Zhang J; Department of Developmental Neurobiology, Memphis, TN, USA., Li X; Department of Pathology, Memphis, TN, USA., Dalton J; Department of Pathology, Memphis, TN, USA., Jonchere B; Department of Tumor Cell Biology, Memphis, TN, USA., Mercer KS; Department of Tumor Cell Biology, Memphis, TN, USA., Currier DG; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Caufield W; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Wang Y; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Xie J; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Broniscer A; Division of Hematology-Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Wetmore C; Exelixis, Inc., Alameda, CA, USA., Upadhyaya SA; Department of Oncology, Memphis, TN, USA., Qaddoumi I; Department of Oncology, Memphis, TN, USA., Klimo P; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Boop F; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA., Gajjar A; Department of Oncology, Memphis, TN, USA., Zhang J; Department of Computational Biology, Memphis, TN, USA., Orr BA; Department of Pathology, Memphis, TN, USA., Robinson GW; Department of Oncology, Memphis, TN, USA., Monje M; Department of Neurology, Stanford University, Stanford, CA, USA., Freeman Iii BB; Preclinical Pharmacokinetics Shared Resource St. Jude Children's Research Hospital, Memphis, TN, USA., Roussel MF; Department of Tumor Cell Biology, Memphis, TN, USA., Northcott PA; Department of Developmental Neurobiology, Memphis, TN, USA., Chen T; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Rankovic Z; Department of Chemical Biology and Therapeutics, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, Memphis, TN, USA.; Department of Computational Biology, Memphis, TN, USA., Chiang J; Department of Pathology, Memphis, TN, USA. Suzanne.Baker@StJude.org., Tinkle CL; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA. Anang.Shelat@StJude.org., Shelat AA; Department of Chemical Biology and Therapeutics, Memphis, TN, USA. Christopher.Tinkle@StJude.org., Baker SJ; Department of Developmental Neurobiology, Memphis, TN, USA. Jason.Chiang@StJude.org. |
| Source: | Nature communications [Nat Commun] 2021 Jul 02; Vol. 12 (1), pp. 4089. Date of Electronic Publication: 2021 Jul 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-24168-8 |
