Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
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| Title: | Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. |
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| Authors: | Armstrong LA; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Lange SM; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Dee Cesare V; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Matthews SP; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Nirujogi RS; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Cole I; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Hope A; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Cunningham F; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Toth R; MRC Reagents and Services, University of Dundee, Dundee, Scotland, United Kingdom., Mukherjee R; Institute of Biochemistry II, Goethe University Frankfurt Medical Faculty, University Hospital, Frankfurt am Main, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany., Bojkova D; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany., Gruber F; National Phenotypic Screening Centre, University of Dundee, Dundee, Scotland, United Kingdom., Gray D; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Wyatt PG; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Cinatl J; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany., Dikic I; Institute of Biochemistry II, Goethe University Frankfurt Medical Faculty, University Hospital, Frankfurt am Main, Germany.; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.; Max Planck Institute of Biophysics, Frankfurt am Main, Germany., Davies P; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom., Kulathu Y; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom. |
| Source: | PloS one [PLoS One] 2021 Jul 16; Vol. 16 (7), pp. e0253364. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0253364 |
