TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
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| Title: | TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis. |
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| Authors: | Sun T; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com., Huang Z; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Liang WC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yin J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lin WY; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wu J; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Vernes JM; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lutman J; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Caplazi P; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Jeet S; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wong T; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wong M; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., DePianto DJ; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Morshead KB; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sun KH; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Modrusan Z; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Vander Heiden JA; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Abbas AR; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Zhang H; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Xu M; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., N'Diaye EN; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wolters PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Yadav R; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sukumaran S; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ghilardi N; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Corpuz R; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Emson C; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Meng YG; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ramalingam TR; Department of Biomarker Discovery OMNI, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lupardus P; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Brightbill HD; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Seshasayee D; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wu Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Arron JR; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com. |
| Source: | Science translational medicine [Sci Transl Med] 2021 Aug 04; Vol. 13 (605). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.abe0407 |
