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TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.

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Title: TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
Authors: Sun T; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com., Huang Z; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Liang WC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yin J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lin WY; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wu J; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Vernes JM; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lutman J; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Caplazi P; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Jeet S; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wong T; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wong M; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., DePianto DJ; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Morshead KB; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sun KH; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Modrusan Z; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Vander Heiden JA; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Abbas AR; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Zhang H; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Xu M; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., N'Diaye EN; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wolters PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Yadav R; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sukumaran S; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ghilardi N; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Corpuz R; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Emson C; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Meng YG; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Ramalingam TR; Department of Biomarker Discovery OMNI, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lupardus P; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Brightbill HD; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Seshasayee D; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wu Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Arron JR; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com.
Source: Science translational medicine [Sci Transl Med] 2021 Aug 04; Vol. 13 (605).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Sun+T%22">Sun T</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com.<br /><searchLink fieldCode="AU" term="%22Huang+Z%22">Huang Z</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Liang+WC%22">Liang WC</searchLink>; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Yin+J%22">Yin J</searchLink>; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lin+WY%22">Lin WY</searchLink>; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Vernes+JM%22">Vernes JM</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lutman+J%22">Lutman J</searchLink>; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Caplazi+P%22">Caplazi P</searchLink>; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Jeet+S%22">Jeet S</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wong+T%22">Wong T</searchLink>; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wong+M%22">Wong M</searchLink>; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22DePianto+DJ%22">DePianto DJ</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Morshead+KB%22">Morshead KB</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Sun+KH%22">Sun KH</searchLink>; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Modrusan+Z%22">Modrusan Z</searchLink>; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+JA%22">Vander Heiden JA</searchLink>; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Abbas+AR%22">Abbas AR</searchLink>; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Xu+M%22">Xu M</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22N'Diaye+EN%22">N'Diaye EN</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Roose-Girma+M%22">Roose-Girma M</searchLink>; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wolters+PJ%22">Wolters PJ</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Yadav+R%22">Yadav R</searchLink>; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Sukumaran+S%22">Sukumaran S</searchLink>; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ghilardi+N%22">Ghilardi N</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Corpuz+R%22">Corpuz R</searchLink>; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Emson+C%22">Emson C</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Meng+YG%22">Meng YG</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ramalingam+TR%22">Ramalingam TR</searchLink>; Department of Biomarker Discovery OMNI, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lupardus+P%22">Lupardus P</searchLink>; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Brightbill+HD%22">Brightbill HD</searchLink>; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Seshasayee+D%22">Seshasayee D</searchLink>; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Arron+JR%22">Arron JR</searchLink>; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com.
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