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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.

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Title: GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Authors: Kremer DM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA., Nelson BS; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Lin L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Yarosz EL; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA., Halbrook CJ; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Kerk SA; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Myers A; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Thurston G; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Hou SW; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Carpenter ES; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Andren AC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Nwosu ZC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Cusmano N; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Wisner S; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Mbah NE; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Shan M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Das NK; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Magnuson B; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Little AC; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Savani MR; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ramos J; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Gao T; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Sastra SA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Palermo CF; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Badgley MA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.; Department of Pathology, Columbia University Medical Center, New York, NY, USA., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Asara JM; Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Olive KP; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.
Source: Nature communications [Nat Commun] 2021 Aug 11; Vol. 12 (1), pp. 4860. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-021-24859-2