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Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.

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Title: Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
Authors: Moehle MS; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology & Therapeutics, Center for Translational Research in Neurodegeneration, University of Florida, Gainesville, Florida 32610, United States., Bender AM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Dickerson JW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Foster DJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Qi A; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Cho HP; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Donsante Y; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States., Peng W; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Bryant Z; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Stillwell KJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Bridges TM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Chang S; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Watson KJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., O'Neill JC; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Engers JL; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Peng L; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Rodriguez AL; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Niswender CM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsley CW; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Hess EJ; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States., Conn PJ; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States., Rook JM; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2021 Aug 02; Vol. 4 (4), pp. 1306-1321. Date of Electronic Publication: 2021 Aug 02 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE
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  Data: Discovery of the First Selective M<subscript>4</subscript> Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
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  Data: <searchLink fieldCode="AU" term="%22Moehle+MS%22">Moehle MS</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology & Therapeutics, Center for Translational Research in Neurodegeneration, University of Florida, Gainesville, Florida 32610, United States.<br /><searchLink fieldCode="AU" term="%22Bender+AM%22">Bender AM</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Dickerson+JW%22">Dickerson JW</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Foster+DJ%22">Foster DJ</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Qi+A%22">Qi A</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Cho+HP%22">Cho HP</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Donsante+Y%22">Donsante Y</searchLink>; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Peng+W%22">Peng W</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Bryant+Z%22">Bryant Z</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Stillwell+KJ%22">Stillwell KJ</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Bridges+TM%22">Bridges TM</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Chang+S%22">Chang S</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Watson+KJ%22">Watson KJ</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22O'Neill+JC%22">O'Neill JC</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Engers+JL%22">Engers JL</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Rodriguez+AL%22">Rodriguez AL</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Niswender+CM%22">Niswender CM</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Lindsley+CW%22">Lindsley CW</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Hess+EJ%22">Hess EJ</searchLink>; Department of Pharmacology & Chemical Biology, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Conn+PJ%22">Conn PJ</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.; Vanderbilt Kennedy Center, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Rook+JM%22">Rook JM</searchLink>; Department of Pharmacology, Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
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  Data: <searchLink fieldCode="JN" term="%22101721411%22">ACS pharmacology & translational science</searchLink> [ACS Pharmacol Transl Sci] 2021 Aug 02; Vol. 4 (4), pp. 1306-1321. <i>Date of Electronic Publication: </i>2021 Aug 02 (<i>Print Publication: </i>2021).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101721411 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2575-9108 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225759108%22">25759108 </searchLink><i>NLM ISO Abbreviation: </i>ACS Pharmacol Transl Sci <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34423268
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        Value: 10.1021/acsptsci.0c00162
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