Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.
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| Title: | Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment. |
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| Authors: | Sun H; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Cao S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Mashl RJ; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Mo CK; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Zaccaria S; Department of Computer Science, Princeton University, Princeton, NJ, USA.; Computational Cancer Genomics Research Group and Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Wendl MC; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.; Department of Mathematics, Washington University in St. Louis, St. Louis, MO, USA.; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA., Davies SR; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Bailey MH; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Primeau TM; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Hoog J; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Mudd JL; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Dean DA 2nd; Seven Bridges Genomics, Inc., Cambridge, Charlestown, MA, USA., Patidar R; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Chen L; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Wyczalkowski MA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Jayasinghe RG; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Rodrigues FM; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Terekhanova NV; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Li Y; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Lim KH; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Wang-Gillam A; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Van Tine BA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Ma CX; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Aft R; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Fuh KC; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Schwarz JK; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, USA., Zevallos JP; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Otolaryngology, Washington University St. Louis, St. Louis, MO, USA., Puram SV; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Otolaryngology, Washington University St. Louis, St. Louis, MO, USA., Dipersio JF; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Davis-Dusenbery B; Seven Bridges Genomics, Inc., Cambridge, Charlestown, MA, USA., Ellis MJ; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Lewis MT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Davies MA; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Herlyn M; The Wistar Institute, Philadelphia, PA, USA., Fang B; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Roth JA; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Welm AL; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Welm BE; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Meric-Bernstam F; The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen F; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Fields RC; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Li S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Govindan R; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Doroshow JH; Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA., Moscow JA; Investigational Drug Branch, National Cancer Institute, Bethesda, MD, USA., Evrard YA; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Chuang JH; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA., Raphael BJ; Department of Computer Science, Princeton University, Princeton, NJ, USA., Ding L; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu. |
| Corporate Authors: | NCI PDXNet Consortium |
| Source: | Nature communications [Nat Commun] 2021 Aug 24; Vol. 12 (1), pp. 5086. Date of Electronic Publication: 2021 Aug 24. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-25177-3 |
