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Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.

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Bibliographic Details
Title: Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
Authors: Luo X; Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China., Cai G; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Guo Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Gao C; Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China., Huang W; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Zhang Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Lu H; Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China., Liu K; Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China., Chen J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Xiong X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Lei J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Zhou X; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China.; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, P.R. China., Wang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, P.R. China., Liu Y; Institute of Marine Drugs/Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China.; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, P.R. China.
Source: Journal of medicinal chemistry [J Med Chem] 2021 Sep 23; Vol. 64 (18), pp. 13918-13932. Date of Electronic Publication: 2021 Sep 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.1c01402