View in EDS

Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.

Saved in:
Bibliographic Details
Title: Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Authors: Carpenter J; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wu G; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wang Y; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Cook EM; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wang T; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Sitkoff D; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Rossi KA; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Mosure K; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Zhuo X; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Cao GG; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Ziegler M; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Azzara AV; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Krupinski J; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Soars MG; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Ellsworth BA; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States., Wacker DA; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Aug 05; Vol. 12 (9), pp. 1413-1420. Date of Electronic Publication: 2021 Aug 05 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 34531950
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Carpenter+J%22">Carpenter J</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Wu+G%22">Wu G</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Cook+EM%22">Cook EM</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Sitkoff+D%22">Sitkoff D</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Rossi+KA%22">Rossi KA</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Mosure+K%22">Mosure K</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Zhuo+X%22">Zhuo X</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Cao+GG%22">Cao GG</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Ziegler+M%22">Ziegler M</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Azzara+AV%22">Azzara AV</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Krupinski+J%22">Krupinski J</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Soars+MG%22">Soars MG</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Ellsworth+BA%22">Ellsworth BA</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.<br /><searchLink fieldCode="AU" term="%22Wacker+DA%22">Wacker DA</searchLink>; Departments of Small Molecule Drug Discovery, Discovery Biology, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2021 Aug 05; Vol. 12 (9), pp. 1413-1420. <i>Date of Electronic Publication: </i>2021 Aug 05 (<i>Print Publication: </i>2021).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101521073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1948-5875 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219485875%22">19485875 </searchLink><i>NLM ISO Abbreviation: </i>ACS Med Chem Lett <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34531950
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acsmedchemlett.1c00198
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1413
    Titles:
      – TitleFull: Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Carpenter J
      – PersonEntity:
          Name:
            NameFull: Wu G
      – PersonEntity:
          Name:
            NameFull: Wang Y
      – PersonEntity:
          Name:
            NameFull: Cook EM
      – PersonEntity:
          Name:
            NameFull: Wang T
      – PersonEntity:
          Name:
            NameFull: Sitkoff D
      – PersonEntity:
          Name:
            NameFull: Rossi KA
      – PersonEntity:
          Name:
            NameFull: Mosure K
      – PersonEntity:
          Name:
            NameFull: Zhuo X
      – PersonEntity:
          Name:
            NameFull: Cao GG
      – PersonEntity:
          Name:
            NameFull: Ziegler M
      – PersonEntity:
          Name:
            NameFull: Azzara AV
      – PersonEntity:
          Name:
            NameFull: Krupinski J
      – PersonEntity:
          Name:
            NameFull: Soars MG
      – PersonEntity:
          Name:
            NameFull: Ellsworth BA
      – PersonEntity:
          Name:
            NameFull: Wacker DA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 08
              Text: 2021 Aug 05
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 1948-5875
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: ACS medicinal chemistry letters
              Type: main
ResultId 1