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A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.

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Title: A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
Authors: Katz JS; Forbes Norris MDA/ALS Research Center, California Pacific Medical Center, San Francisco, California, USA., Rothstein JD; Johns Hopkins Hospital, Baltimore, Maryland, USA., Cudkowicz ME; Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Genge A; Montreal Neurological Institute & Hospital, Montreal, QC, Canada., Oskarsson B; Mayo Clinic, Jacksonville, Florida, USA., Hains AB; Genentech, Inc., South San Francisco, California, USA., Chen C; Genentech, Inc., South San Francisco, California, USA., Galanter J; Genentech, Inc., South San Francisco, California, USA., Burgess BL; Genentech, Inc., South San Francisco, California, USA., Cho W; Genentech, Inc., South San Francisco, California, USA., Kerchner GA; F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Yeh FL; Genentech, Inc., South San Francisco, California, USA., Ghosh AS; Genentech, Inc., South San Francisco, California, USA., Cheeti S; Genentech, Inc., South San Francisco, California, USA., Brooks L; Genentech, Inc., South San Francisco, California, USA., Honigberg L; Genentech, Inc., South San Francisco, California, USA., Couch JA; Genentech, Inc., South San Francisco, California, USA., Rothenberg ME; Genentech, Inc., South San Francisco, California, USA., Brunstein F; Genentech, Inc., South San Francisco, California, USA., Sharma KR; University of Miami Hospital (CRC), Miami, Florida, USA., van den Berg L; UMC Utrecht, Utrecht, The Netherlands., Berry JD; Neurological Clinical Research Institute, Boston, Massachusetts, USA., Glass JD; Emory University School of Medicine, Atlanta, Georgia, USA.
Source: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2022 Jan; Vol. 9 (1), pp. 50-66. Date of Electronic Publication: 2022 Jan 10.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
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  Data: <searchLink fieldCode="AU" term="%22Katz+JS%22">Katz JS</searchLink>; Forbes Norris MDA/ALS Research Center, California Pacific Medical Center, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Rothstein+JD%22">Rothstein JD</searchLink>; Johns Hopkins Hospital, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cudkowicz+ME%22">Cudkowicz ME</searchLink>; Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Genge+A%22">Genge A</searchLink>; Montreal Neurological Institute & Hospital, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Oskarsson+B%22">Oskarsson B</searchLink>; Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Hains+AB%22">Hains AB</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Galanter+J%22">Galanter J</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Burgess+BL%22">Burgess BL</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cho+W%22">Cho W</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Kerchner+GA%22">Kerchner GA</searchLink>; F. Hoffmann-La Roche, Ltd., Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yeh+FL%22">Yeh FL</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+AS%22">Ghosh AS</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cheeti+S%22">Cheeti S</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Brooks+L%22">Brooks L</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Honigberg+L%22">Honigberg L</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Couch+JA%22">Couch JA</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Rothenberg+ME%22">Rothenberg ME</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Brunstein+F%22">Brunstein F</searchLink>; Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+KR%22">Sharma KR</searchLink>; University of Miami Hospital (CRC), Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22van+den+Berg+L%22">van den Berg L</searchLink>; UMC Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Berry+JD%22">Berry JD</searchLink>; Neurological Clinical Research Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Glass+JD%22">Glass JD</searchLink>; Emory University School of Medicine, Atlanta, Georgia, USA.
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  Data: <searchLink fieldCode="JN" term="%22101623278%22">Annals of clinical and translational neurology</searchLink> [Ann Clin Transl Neurol] 2022 Jan; Vol. 9 (1), pp. 50-66. <i>Date of Electronic Publication: </i>2022 Jan 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+Periodicals%2C+Inc+on+behalf+of+American+Neurological+Association%22">Wiley Periodicals, Inc on behalf of American Neurological Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101623278 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2328-9503 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223289503%22">23289503 </searchLink><i>NLM ISO Abbreviation: </i>Ann Clin Transl Neurol <i>Subsets: </i>MEDLINE
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