Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs.

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Title: Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs.
Authors: Matsuda Y; Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Ye J; Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Yasukawa M; Division of Cancer Stem Cell, National Cancer Center Research Institute, Tokyo, Japan., Yamakawa K; Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Mukai Y; Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Machitani M; Division of Cancer Stem Cell, National Cancer Center Research Institute, Tokyo, Japan., Daigo Y; Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan.; Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Otsu, Japan.; Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan., Miyagi Y; Kanagawa Cancer Center Research Institute, Yokohama, Japan., Yokose T; Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan., Oshima T; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan., Ito H; Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan., Morinaga S; Department of Hepato-Biliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan., Kishida T; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan., Minamoto T; Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan., Yamada S; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan., Takei J; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan., Kaneko MK; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan., Kojima M; Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan., Kaneko S; Department of Gastroenterology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Masaki T; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Hirata M; Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Haba R; Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Kontani K; Department of Thoracic, Breast and Endocrine Surgery, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Kanaji N; Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Miyatake N; Department of Hygiene, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Okano K; Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Kita-gun, Japan., Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan., Masutomi K; Division of Cancer Stem Cell, National Cancer Center Research Institute, Tokyo, Japan.
Source: The Journal of pathology [J Pathol] 2022 Jun; Vol. 257 (2), pp. 172-185. Date of Electronic Publication: 2022 Mar 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1096-9896
DOI:10.1002/path.5876