Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.

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Title: Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.
Authors: Nijhuis A; Department of Surgery & Cancer, Imperial College London, London, UK., Sikka A; Department of Surgery & Cancer, Imperial College London, London, UK., Yogev O; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Herendi L; Department of Surgery & Cancer, Imperial College London, London, UK., Balcells C; Department of Surgery & Cancer, Imperial College London, London, UK., Ma Y; Department of Surgery & Cancer, Imperial College London, London, UK., Poon E; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Eckold C; Department of Surgery & Cancer, Imperial College London, London, UK., Valbuena GN; Department of Surgery & Cancer, Imperial College London, London, UK., Xu Y; Department of Surgery & Cancer, Imperial College London, London, UK., Liu Y; Department of Surgery & Cancer, Imperial College London, London, UK., da Costa BM; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Gruet M; Department of Surgery & Cancer, Imperial College London, London, UK., Wickremesinghe C; Department of Surgery & Cancer, Imperial College London, London, UK., Benito A; Department of Surgery & Cancer, Imperial College London, London, UK., Kramer H; Medical Research Council London Institute of Medical Science, London, UK., Montoya A; Medical Research Council London Institute of Medical Science, London, UK., Carling D; Medical Research Council London Institute of Medical Science, London, UK., Want EJ; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Jamin Y; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London and Royal Marsden NHS Trust, London, UK., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Keun HC; Department of Surgery & Cancer, Imperial College London, London, UK. h.keun@imperial.ac.uk.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. h.keun@imperial.ac.uk.
Source: Nature communications [Nat Commun] 2022 Mar 16; Vol. 13 (1), pp. 1380. Date of Electronic Publication: 2022 Mar 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-022-28907-3