Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.
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| Title: | Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci. |
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| Authors: | Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Chan LS; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Bose D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., VandeHaar P; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, 63108, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Welch R; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Yu K; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Fernandes Silva L; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland., Service SK; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, 90024, USA., Zhang D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Hector EC; Department of Statistics, North Carolina State University, Raleigh, NC, 27695, USA., Young E; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, 63108, USA.; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA., Ganel L; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, 63108, USA., Das I; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, 63108, USA., Abel H; Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Erdos MR; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Bonnycastle LL; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland.; Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, 70210, Finland., Stitziel NO; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, 63108, USA.; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA.; Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA., Hall IM; Center for Genomic Health, Department of Genetics, Yale University, New Haven, CT, 06510, USA., Wagner GR; Metabolon, Inc., Morrisville, NC, 27560, USA., Kang J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Morrison J; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Collins FS; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Ripatti S; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, 00290, Finland.; Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.; Broad Institute of MIT & Harvard, Cambridge, MA, 02142, USA., Palotie A; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, 00290, Finland.; Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, 02114, USA., Freimer NB; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, 90024, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Wen X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, 02139, USA. Eric.Fauman@pfizer.com., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70210, Finland. markku.laakso@uef.fi., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA. boehnke@umich.edu. |
| Corporate Authors: | FinnGen |
| Source: | Nature communications [Nat Commun] 2022 Mar 28; Vol. 13 (1), pp. 1644. Date of Electronic Publication: 2022 Mar 28. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-29143-5 |
