ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.

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Title: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Authors: Li S; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Yang H; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Li W; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Liu JY; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Ren LW; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Yang YH; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Ge BB; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Zhang YZ; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Fu WQ; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Zheng XJ; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China., Du GH; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China. dugh@imm.ac.cn.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. dugh@imm.ac.cn., Wang JH; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China. wjh@imm.ac.cn.; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. wjh@imm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2022 Oct; Vol. 43 (10), pp. 2709-2722. Date of Electronic Publication: 2022 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-022-00894-7