A Pharmacokinetic Analysis of Tobramycin in Patients Less than Five Years of Age with Cystic Fibrosis: Assessment of Target Attainment with Extended-Interval Dosing through Simulation.

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Title: A Pharmacokinetic Analysis of Tobramycin in Patients Less than Five Years of Age with Cystic Fibrosis: Assessment of Target Attainment with Extended-Interval Dosing through Simulation.
Authors: Downes KJ; Division of Infectious, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Grim A; Department of Pharmacy, Texas Children's Hospital, Houston, Texas, USA., Shanley L; Clinical Pharmacy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Rubenstein RC; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA., Zuppa AF; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Anesthesiology and Critical Care, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Gastonguay MR; Metrum Research Group, Tariffville, Connecticut, USA.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 May 17; Vol. 66 (5), pp. e0237721. Date of Electronic Publication: 2022 Apr 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Downes+KJ%22">Downes KJ</searchLink>; Division of Infectious, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Grim+A%22">Grim A</searchLink>; Department of Pharmacy, Texas Children's Hospital, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Shanley+L%22">Shanley L</searchLink>; Clinical Pharmacy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Rubenstein+RC%22">Rubenstein RC</searchLink>; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Zuppa+AF%22">Zuppa AF</searchLink>; Center for Clinical Pharmacology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Anesthesiology and Critical Care, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gastonguay+MR%22">Gastonguay MR</searchLink>; Metrum Research Group, Tariffville, Connecticut, USA.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2022 May 17; Vol. 66 (5), pp. e0237721. <i>Date of Electronic Publication: </i>2022 Apr 28.
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      – TitleFull: A Pharmacokinetic Analysis of Tobramycin in Patients Less than Five Years of Age with Cystic Fibrosis: Assessment of Target Attainment with Extended-Interval Dosing through Simulation.
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