Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors.
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| Title: | Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors. |
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| Authors: | Parkhurst A; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Wang SZ; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Findlay TR; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Malebranche KJ; Division of Cell Biology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Odabas A; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Alt J; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Maxwell MJ; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Kaur H; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Peer CJ; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Figg WD; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Warren KE; Pediatric Oncology Branch, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.; Dana Farber Cancer Institute (KEW), 450 Brookline Ave, Boston, MA, 02215, USA., Slusher BS; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Eberhart CG; Division of Neuropathology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Raabe EH; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Rubens JA; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu. |
| Source: | Cell death & disease [Cell Death Dis] 2022 Apr 28; Vol. 13 (4), pp. 410. Date of Electronic Publication: 2022 Apr 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-022-04868-9 |
