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Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors.

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Title: Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors.
Authors: Parkhurst A; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Wang SZ; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Findlay TR; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Malebranche KJ; Division of Cell Biology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Odabas A; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Alt J; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Maxwell MJ; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Kaur H; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Peer CJ; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Figg WD; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA., Warren KE; Pediatric Oncology Branch, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.; Dana Farber Cancer Institute (KEW), 450 Brookline Ave, Boston, MA, 02215, USA., Slusher BS; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Eberhart CG; Division of Neuropathology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Raabe EH; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA., Rubens JA; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu.
Source: Cell death & disease [Cell Death Dis] 2022 Apr 28; Vol. 13 (4), pp. 410. Date of Electronic Publication: 2022 Apr 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Parkhurst+A%22">Parkhurst A</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SZ%22">Wang SZ</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Findlay+TR%22">Findlay TR</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Malebranche+KJ%22">Malebranche KJ</searchLink>; Division of Cell Biology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Odabas+A%22">Odabas A</searchLink>; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Alt+J%22">Alt J</searchLink>; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Maxwell+MJ%22">Maxwell MJ</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+H%22">Kaur H</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Peer+CJ%22">Peer CJ</searchLink>; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Figg+WD%22">Figg WD</searchLink>; Clinical Pharmacology Program, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.<br /><searchLink fieldCode="AU" term="%22Warren+KE%22">Warren KE</searchLink>; Pediatric Oncology Branch, National Cancer Institute at the National Institutes of Health, 37 Convent Dr, Bethesda, MD, 20892, USA.; Dana Farber Cancer Institute (KEW), 450 Brookline Ave, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Slusher+BS%22">Slusher BS</searchLink>; Johns Hopkins Drug Discovery, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Department of Neurology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Eberhart+CG%22">Eberhart CG</searchLink>; Division of Neuropathology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Raabe+EH%22">Raabe EH</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.<br /><searchLink fieldCode="AU" term="%22Rubens+JA%22">Rubens JA</searchLink>; Division of Pediatric Oncology, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA. Jrubens6@jhmi.edu.
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