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Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming.

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Title: Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming.
Authors: Umar S; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Palasiewicz K; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Meyer A; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Kumar P; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA., Prabhakar BS; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA., Volin MV; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA., Rahat R; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Al-Awqati M; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Chang HJ; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Zomorrodi RK; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA., Rehman J; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, Chicago, IL, USA.; Department of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., Shahrara S; Jesse Brown VA Medical Center, Chicago, IL, USA. shahrara@uic.edu.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA. shahrara@uic.edu.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 May 19; Vol. 79 (6), pp. 301. Date of Electronic Publication: 2022 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming.
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  Data: <searchLink fieldCode="AU" term="%22Umar+S%22">Umar S</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Palasiewicz+K%22">Palasiewicz K</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+A%22">Meyer A</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Prabhakar+BS%22">Prabhakar BS</searchLink>; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Volin+MV%22">Volin MV</searchLink>; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rahat+R%22">Rahat R</searchLink>; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Al-Awqati+M%22">Al-Awqati M</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Chang+HJ%22">Chang HJ</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Zomorrodi+RK%22">Zomorrodi RK</searchLink>; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA.<br /><searchLink fieldCode="AU" term="%22Rehman+J%22">Rehman J</searchLink>; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, Chicago, IL, USA.; Department of Medicine, Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shahrara+S%22">Shahrara S</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA. shahrara@uic.edu.; Department of Medicine, Division of Rheumatology, University of Illinois at Chicago, 840 S Wood Street, CSB suite 1114, Chicago, IL, 60612, USA. shahrara@uic.edu.
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        Value: 10.1007/s00018-022-04329-8
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