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Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.

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Title: Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.
Authors: Hou J; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Hess JL; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Armstrong N; Mathematics and Statistics, Curtin University, Perth, WA, Australia., Bis JC; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Grenier-Boley B; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France., Karlsson IK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden., Leonenko G; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK., Numbers K; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., O'Brien EK; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Shadrin A; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Yang Q; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Andreassen OA; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Gatz M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA., Kochan NA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Lambert JC; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France., Laws SM; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Masters CL; The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia., Mather KA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the Netherlands., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Williams J; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Fan CC; Department of Cognitive Science, University of California San Diego, La Jolla, CA, USA., Faraone SV; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Fennema-Notestine C; Departments of Psychiatry and Radiology, University of California San Diego, La Jolla, CA, USA., Lin SJ; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Escott-Price V; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Holmans P; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Seshadri S; Department of Neurology, School of Medicine, Boston University, Boston, MA, USA., Tsuang MT; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Kremen WS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Glatt SJ; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: Translational psychiatry [Transl Psychiatry] 2022 Jul 25; Vol. 12 (1), pp. 296. Date of Electronic Publication: 2022 Jul 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2158-3188
DOI:10.1038/s41398-022-02055-0