View in EDS HTML Full Text PDF Full Text

Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.

Saved in:
Bibliographic Details
Title: Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.
Authors: Hou J; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Hess JL; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Armstrong N; Mathematics and Statistics, Curtin University, Perth, WA, Australia., Bis JC; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Grenier-Boley B; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France., Karlsson IK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden., Leonenko G; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK., Numbers K; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., O'Brien EK; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Shadrin A; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Yang Q; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Andreassen OA; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Gatz M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA., Kochan NA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Lambert JC; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France., Laws SM; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Masters CL; The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia., Mather KA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Posthuma D; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the Netherlands., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Williams J; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Fan CC; Department of Cognitive Science, University of California San Diego, La Jolla, CA, USA., Faraone SV; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA., Fennema-Notestine C; Departments of Psychiatry and Radiology, University of California San Diego, La Jolla, CA, USA., Lin SJ; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Escott-Price V; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Holmans P; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK., Seshadri S; Department of Neurology, School of Medicine, Boston University, Boston, MA, USA., Tsuang MT; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Kremen WS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Glatt SJ; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: Translational psychiatry [Transl Psychiatry] 2022 Jul 25; Vol. 12 (1), pp. 296. Date of Electronic Publication: 2022 Jul 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 35879306
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Hou+J%22">Hou J</searchLink>; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hess+JL%22">Hess JL</searchLink>; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+N%22">Armstrong N</searchLink>; Mathematics and Statistics, Curtin University, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Grenier-Boley+B%22">Grenier-Boley B</searchLink>; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France.<br /><searchLink fieldCode="AU" term="%22Karlsson+IK%22">Karlsson IK</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Aging Research Network - Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Jönköping, Sweden.<br /><searchLink fieldCode="AU" term="%22Leonenko+G%22">Leonenko G</searchLink>; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Numbers+K%22">Numbers K</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+EK%22">O'Brien EK</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Shadrin+A%22">Shadrin A</searchLink>; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Thalamuthu+A%22">Thalamuthu A</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Brodaty+H%22">Brodaty H</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gatz+M%22">Gatz M</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kochan+NA%22">Kochan NA</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lambert+JC%22">Lambert JC</searchLink>; U1167-RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, F-59000, Lille, France.<br /><searchLink fieldCode="AU" term="%22Laws+SM%22">Laws SM</searchLink>; Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Masters+CL%22">Masters CL</searchLink>; The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mather+KA%22">Mather KA</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pedersen+NL%22">Pedersen NL</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Posthuma+D%22">Posthuma D</searchLink>; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sachdev+PS%22">Sachdev PS</searchLink>; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+J%22">Williams J</searchLink>; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Fan+CC%22">Fan CC</searchLink>; Department of Cognitive Science, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Faraone+SV%22">Faraone SV</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fennema-Notestine+C%22">Fennema-Notestine C</searchLink>; Departments of Psychiatry and Radiology, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lin+SJ%22">Lin SJ</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Escott-Price+V%22">Escott-Price V</searchLink>; Dementia Research Institute, School of Medicine, Cardiff University, Cardiff, UK.; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Holmans+P%22">Holmans P</searchLink>; Division of Psychological Medicine and Clinical Neurology and Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Seshadri+S%22">Seshadri S</searchLink>; Department of Neurology, School of Medicine, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tsuang+MT%22">Tsuang MT</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kremen+WS%22">Kremen WS</searchLink>; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Glatt+SJ%22">Glatt SJ</searchLink>; Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab), SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.; Department of Public Health and Preventive Medicine, SUNY Upstate Medical University, Syracuse, NY, USA. stephen.glatt@psychgenelab.com.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Disease+Neuroimaging+Initiative%22">Alzheimer’s Disease Neuroimaging Initiative</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101562664%22">Translational psychiatry</searchLink> [Transl Psychiatry] 2022 Jul 25; Vol. 12 (1), pp. 296. <i>Date of Electronic Publication: </i>2022 Jul 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101562664 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2158-3188 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221583188%22">21583188 </searchLink><i>NLM ISO Abbreviation: </i>Transl Psychiatry <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35879306
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41398-022-02055-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 296
    Titles:
      – TitleFull: Polygenic resilience scores capture protective genetic effects for Alzheimer's disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hou J
      – PersonEntity:
          Name:
            NameFull: Hess JL
      – PersonEntity:
          Name:
            NameFull: Armstrong N
      – PersonEntity:
          Name:
            NameFull: Bis JC
      – PersonEntity:
          Name:
            NameFull: Grenier-Boley B
      – PersonEntity:
          Name:
            NameFull: Karlsson IK
      – PersonEntity:
          Name:
            NameFull: Leonenko G
      – PersonEntity:
          Name:
            NameFull: Numbers K
      – PersonEntity:
          Name:
            NameFull: O'Brien EK
      – PersonEntity:
          Name:
            NameFull: Shadrin A
      – PersonEntity:
          Name:
            NameFull: Thalamuthu A
      – PersonEntity:
          Name:
            NameFull: Yang Q
      – PersonEntity:
          Name:
            NameFull: Andreassen OA
      – PersonEntity:
          Name:
            NameFull: Brodaty H
      – PersonEntity:
          Name:
            NameFull: Gatz M
      – PersonEntity:
          Name:
            NameFull: Kochan NA
      – PersonEntity:
          Name:
            NameFull: Lambert JC
      – PersonEntity:
          Name:
            NameFull: Laws SM
      – PersonEntity:
          Name:
            NameFull: Masters CL
      – PersonEntity:
          Name:
            NameFull: Mather KA
      – PersonEntity:
          Name:
            NameFull: Pedersen NL
      – PersonEntity:
          Name:
            NameFull: Posthuma D
      – PersonEntity:
          Name:
            NameFull: Sachdev PS
      – PersonEntity:
          Name:
            NameFull: Williams J
      – PersonEntity:
          Name:
            NameFull: Fan CC
      – PersonEntity:
          Name:
            NameFull: Faraone SV
      – PersonEntity:
          Name:
            NameFull: Fennema-Notestine C
      – PersonEntity:
          Name:
            NameFull: Lin SJ
      – PersonEntity:
          Name:
            NameFull: Escott-Price V
      – PersonEntity:
          Name:
            NameFull: Holmans P
      – PersonEntity:
          Name:
            NameFull: Seshadri S
      – PersonEntity:
          Name:
            NameFull: Tsuang MT
      – PersonEntity:
          Name:
            NameFull: Kremen WS
      – PersonEntity:
          Name:
            NameFull: Glatt SJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 07
              Text: 2022 Jul 25
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2158-3188
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Translational psychiatry
              Type: main
ResultId 1