Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
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| Title: | Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses. |
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| Authors: | Solomon S; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. shiden.solomon@kcl.ac.uk.; UK Dementia Research Institute, King's College London, London, UK. shiden.solomon@kcl.ac.uk., Sampathkumar NK; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK.; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, UK., Carre I; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Mondal M; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Chennell G; Wohl Cellular Imaging Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Vernon AC; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK., Ruepp MD; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Mitchell JC; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. jacqueline.mitchell@kcl.ac.uk. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Jul 27; Vol. 79 (8), pp. 453. Date of Electronic Publication: 2022 Jul 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1420-9071 |
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| DOI: | 10.1007/s00018-022-04473-1 |
