Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial.

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Title: Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial.
Authors: Jenkin D; Jenner Institute, University of Oxford, Oxford, UK; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK., Ritchie AJ; Jenner Institute, University of Oxford, Oxford, UK., Aboagye J; Jenner Institute, University of Oxford, Oxford, UK., Fedosyuk S; Jenner Institute, University of Oxford, Oxford, UK., Thorley L; Jenner Institute, University of Oxford, Oxford, UK., Provstgaad-Morys S; Jenner Institute, University of Oxford, Oxford, UK., Sanders H; Jenner Institute, University of Oxford, Oxford, UK., Bellamy D; Jenner Institute, University of Oxford, Oxford, UK., Makinson R; Jenner Institute, University of Oxford, Oxford, UK., Xiang ZQ; Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA., Bolam E; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Tarrant R; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Ramos Lopez F; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK., Platt A; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK., Poulton I; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK., Green C; Clinical Biomanufacturing Facility, University of Oxford, Oxford, UK., Ertl HCJ; Wistar Institute of Anatomy & Biology, Philadelphia, PA, USA., Ewer KJ; Jenner Institute, University of Oxford, Oxford, UK., Douglas AD; Jenner Institute, University of Oxford, Oxford, UK. Electronic address: sandy.douglas@ndm.ox.ac.uk.
Source: The Lancet. Microbe [Lancet Microbe] 2022 Sep; Vol. 3 (9), pp. e663-e671. Date of Electronic Publication: 2022 Jul 27.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-5247
DOI:10.1016/S2666-5247(22)00126-4