Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors.
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| Title: | Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors. |
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| Authors: | Bhadra AK; Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8228, St. Louis, MO, 63110, USA., Rau MJ; Washington University Center for Cellular Imaging (WUCCI), Washington University School of Medicine, St. Louis, MO, USA., Daw JA; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, USA., Fitzpatrick JAJ; Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8228, St. Louis, MO, 63110, USA.; Washington University Center for Cellular Imaging (WUCCI), Washington University School of Medicine, St. Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA., Weihl CC; Department of Neurology, Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO, USA., True HL; Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8228, St. Louis, MO, 63110, USA. heather.true@wustl.edu. |
| Source: | Nature communications [Nat Commun] 2022 Aug 05; Vol. 13 (1), pp. 4570. Date of Electronic Publication: 2022 Aug 05. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-32318-9 |
