Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
Saved in:
| Title: | Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. |
|---|---|
| Authors: | Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Hvinden IC; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Herold RA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., Finch A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Wood J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Morgan M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Staudt M; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany., Clifton IJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Armstrong FA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Redmond J; GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK., Bardella C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. martine.abboud@lau.edu.; Department of Natural Sciences, Lebanese American University, Byblos/Beirut, Lebanon. martine.abboud@lau.edu., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk. |
| Source: | Nature communications [Nat Commun] 2022 Aug 15; Vol. 13 (1), pp. 4785. Date of Electronic Publication: 2022 Aug 15. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-022-32436-4 |
