A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.
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| Title: | A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. |
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| Authors: | Voloudakis G; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.; Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA. georgios.voloudakis@mssm.edu., Vicari JM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Venkatesh S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA., Hoffman GE; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dobrindt K; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Yale University, New Haven, CT, USA., Zhang W; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Beckmann ND; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Higgins CA; Department of Microbiology, Grossman School of Medicine, New York University, New York, NY, USA.; Department of Medicine, Grossman School of Medicine, New York University, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University, New York, NY, USA., Argyriou S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jiang S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoagland D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Virus Engineering Center for Therapeutics and Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gao L; Biostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.; VA Portland Health Care System, Portland, OR, USA., Corvelo A; New York Genome Center, New York, NY, USA., Cho K; VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lee KM; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA., Bian J; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Division of Epidemiology, University of Utah, Salt Lake City, UT, USA., Lee JS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Iyengar SK; Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; VA Northeast Ohio Healthcare System, Cleveland VA Medical Center, Cleveland, OH, USA., Luoh SW; VA Portland Health Care System, Portland, OR, USA.; Department of Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Akbarian S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Striker R; Division of Infectious Diseases, Department of Medicine, University of Wisconsin, Madison, WI, USA.; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Assimes TL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Schadt EE; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Sema4, Stamford, CT, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Division of Epidemiology, University of Utah, Salt Lake City, UT, USA., Merad M; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., tenOever BR; Department of Microbiology, Grossman School of Medicine, New York University, New York, NY, USA.; Department of Medicine, Grossman School of Medicine, New York University, New York, NY, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Virus Engineering Center for Therapeutics and Research, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Charney AW; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brennand KJ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Yale University, New Haven, CT, USA., Fullard JF; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roussos P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.; Mental Illness Research, Education, and Clinical Center (VISN 2 South), James J. Peters VA Medical Center, Bronx, NY, USA. panagiotis.roussos@mssm.edu. |
| Corporate Authors: | Mount Sinai COVID-19 Biobank, VA Million Veteran Program COVID-19 Science Initiative |
| Source: | NPJ genomic medicine [NPJ Genom Med] 2022 Sep 05; Vol. 7 (1), pp. 52. Date of Electronic Publication: 2022 Sep 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature in partnership with the Center of Excellence in Genomic Medicine Research at King Abdulaziz University Country of Publication: England NLM ID: 101685193 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7944 (Electronic) Linking ISSN: 20567944 NLM ISO Abbreviation: NPJ Genom Med Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2056-7944 |
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| DOI: | 10.1038/s41525-022-00324-x |
