Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.
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| Title: | Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration. |
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| Authors: | Gerhardy S; Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, CA, USA., Ultsch M; Department of Structural Biology, Genentech Inc., San Francisco, CA, USA., Tang W; Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, CA, USA., Green E; Department of Structural Biology, Genentech Inc., San Francisco, CA, USA., Holden JK; Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, CA, USA., Li W; Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, CA, USA., Estevez A; Department of Structural Biology, Genentech Inc., San Francisco, CA, USA., Arthur C; Department of Structural Biology, Genentech Inc., San Francisco, CA, USA., Tom I; Department of OMNI Biomarker Development, Genentech Inc., San Francisco, CA, USA., Rohou A; Department of Structural Biology, Genentech Inc., San Francisco, CA, USA., Kirchhofer D; Department of Early Discovery Biochemistry, Genentech Inc., San Francisco, CA, USA. dak@gene.com. |
| Source: | Nature communications [Nat Commun] 2022 Sep 05; Vol. 13 (1), pp. 5222. Date of Electronic Publication: 2022 Sep 05. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-32760-9 |
