Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.

Saved in:
Bibliographic Details
Title: Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.
Authors: Padilla AM; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., Wang W; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., Akama T; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Carter DS; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Easom E; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Freund Y; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Halladay JS; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Liu Y; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Hamer SA; College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA., Hodo CL; College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA., Wilkerson GK; Michale E. Keeling Center for Comparative Medicine and Research of The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA., Orr D; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., White B; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., George A; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., Shen H; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA., Jin Y; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA., Wang MZ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS, USA., Tse S; Pharmacokinetics, Dynamics and Metabolism, Worldwide Research, Pfizer Inc., New York, NY, USA., Jacobs RT; Anacor Pharmaceuticals, Inc, Palo Alto, CA, USA., Tarleton RL; Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, USA. tarleton@uga.edu.
Source: Nature microbiology [Nat Microbiol] 2022 Oct; Vol. 7 (10), pp. 1536-1546. Date of Electronic Publication: 2022 Sep 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-022-01211-y