Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening.
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| Title: | Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. |
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| Authors: | DeWeirdt PC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., McGee AV; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., Zheng F; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., Nwolah I; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Arbor Biotechnologies, Cambridge, MA, USA., Hegde M; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Thermo Fisher Scientific, Carlsbad, CA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA. jdoench@broadinstitute.org. |
| Source: | Nature communications [Nat Commun] 2022 Sep 06; Vol. 13 (1), pp. 5255. Date of Electronic Publication: 2022 Sep 06. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-33024-2 |
