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Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening.

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Title: Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening.
Authors: DeWeirdt PC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., McGee AV; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., Zheng F; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA., Nwolah I; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Arbor Biotechnologies, Cambridge, MA, USA., Hegde M; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Thermo Fisher Scientific, Carlsbad, CA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA. jdoench@broadinstitute.org.
Source: Nature communications [Nat Commun] 2022 Sep 06; Vol. 13 (1), pp. 5255. Date of Electronic Publication: 2022 Sep 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening.
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  Data: <searchLink fieldCode="AU" term="%22DeWeirdt+PC%22">DeWeirdt PC</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22McGee+AV%22">McGee AV</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+F%22">Zheng F</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nwolah+I%22">Nwolah I</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Arbor Biotechnologies, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hegde+M%22">Hegde M</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA.; Thermo Fisher Scientific, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doench+JG%22">Doench JG</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA, USA. jdoench@broadinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Sep 06; Vol. 13 (1), pp. 5255. <i>Date of Electronic Publication: </i>2022 Sep 06.
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        Value: 10.1038/s41467-022-33024-2
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      – TitleFull: Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening.
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