BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
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| Title: | BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. |
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| Authors: | Shaashua L; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Ben-Shmuel A; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Pevsner-Fischer M; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Friedman G; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Levi-Galibov O; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Nandakumar S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Barki D; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Nevo R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Brown LE; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Zhang W; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Stein Y; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Lior C; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Kim HS; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Graduate School of Medical Science, Brain Korea 21 Project, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea., Bojmar L; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Jarnagin WR; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lecomte N; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mayer S; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Stok R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Bishara H; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Hamodi R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel., Levy-Lahad E; The Fuld Family Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Golan T; Oncology Institute, Sheba Medical Center at Tel-Hashomer, Tel Aviv University, Tel Aviv, Israel., Porco JA Jr; Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schultz N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tuveson DA; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA., Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Kelsen D; Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA., Scherz-Shouval R; Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel. ruth.shouval@weizmann.ac.il. |
| Source: | Nature communications [Nat Commun] 2022 Oct 31; Vol. 13 (1), pp. 6513. Date of Electronic Publication: 2022 Oct 31. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-34081-3 |
