The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.

Saved in:
Bibliographic Details
Title: The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.
Authors: Toelzer C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Gupta K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Yadav SKN; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Hodgson L; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Williamson MK; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Buzas D; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK., Borucu U; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Powers K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Stenner R; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Vasileiou K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Garzoni F; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Fitzgerald D; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Payré C; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France., Gautam G; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Lambeau G; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France., Davidson AD; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Verkade P; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Frank M; Biognos AB, Box 8963, 40274 Göteborg, Sweden., Berger I; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK., Schaffitzel C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.
Source: Science advances [Sci Adv] 2022 Nov 25; Vol. 8 (47), pp. eadc9179. Date of Electronic Publication: 2022 Nov 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adc9179