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The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.

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Title: The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.
Authors: Toelzer C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Gupta K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Yadav SKN; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Hodgson L; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Williamson MK; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Buzas D; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK., Borucu U; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Powers K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Stenner R; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Vasileiou K; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Garzoni F; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Fitzgerald D; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK., Payré C; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France., Gautam G; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Lambeau G; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France., Davidson AD; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK., Verkade P; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK., Frank M; Biognos AB, Box 8963, 40274 Göteborg, Sweden., Berger I; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK., Schaffitzel C; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.
Source: Science advances [Sci Adv] 2022 Nov 25; Vol. 8 (47), pp. eadc9179. Date of Electronic Publication: 2022 Nov 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.
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  Data: <searchLink fieldCode="AU" term="%22Toelzer+C%22">Toelzer C</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.<br /><searchLink fieldCode="AU" term="%22Yadav+SKN%22">Yadav SKN</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Hodgson+L%22">Hodgson L</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Williamson+MK%22">Williamson MK</searchLink>; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Buzas+D%22">Buzas D</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Borucu+U%22">Borucu U</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Powers+K%22">Powers K</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Stenner+R%22">Stenner R</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Vasileiou+K%22">Vasileiou K</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Garzoni+F%22">Garzoni F</searchLink>; Imophoron Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+D%22">Fitzgerald D</searchLink>; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.<br /><searchLink fieldCode="AU" term="%22Payré+C%22">Payré C</searchLink>; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France.<br /><searchLink fieldCode="AU" term="%22Gautam+G%22">Gautam G</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Lambeau+G%22">Lambeau G</searchLink>; Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France.<br /><searchLink fieldCode="AU" term="%22Davidson+AD%22">Davidson AD</searchLink>; Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, UK.<br /><searchLink fieldCode="AU" term="%22Verkade+P%22">Verkade P</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.<br /><searchLink fieldCode="AU" term="%22Frank+M%22">Frank M</searchLink>; Biognos AB, Box 8963, 40274 Göteborg, Sweden.<br /><searchLink fieldCode="AU" term="%22Berger+I%22">Berger I</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Max Planck Bristol Centre for Minimal Biology, Cantock's Close, Bristol BS8 1TS, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.<br /><searchLink fieldCode="AU" term="%22Schaffitzel+C%22">Schaffitzel C</searchLink>; School of Biochemistry, University of Bristol, 1 Tankard's Close, Bristol BS8 1TD, UK.; Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK.; Halo Therapeutics Ltd., St. Philips Central, Albert Rd, Bristol BS2 0XJ, UK.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2022 Nov 25; Vol. 8 (47), pp. eadc9179. <i>Date of Electronic Publication: </i>2022 Nov 23.
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