Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
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| Title: | Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis. |
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| Authors: | Chavarria-Smith J; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Chiu CPC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Jackman JK; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yin J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Zhang J; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Hackney JA; Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lin WY; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Tyagi T; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sun Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Tao J; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Dunlap D; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Morton WD; Confluence Discovery Technologies Inc., 4320 Duncan Ave, Suite 400, St. Louis, MO 63108, USA., Ghodge SV; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Maun HR; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Li H; Department of Protein Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Hernandez-Barry H; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Chen E; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Liu J; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Tam C; Department of Biomolecular Resources, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yaspan BL; Department of Human Genetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Cai H; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Balazs M; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Arron JR; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Li J; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wittwer AJ; Confluence Discovery Technologies Inc., 4320 Duncan Ave, Suite 400, St. Louis, MO 63108, USA., Pappu R; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Austin CD; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lee WP; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lazarus RA; Departments of Biological Chemistry and Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Sudhamsu J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Koerber JT; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yi T; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2022 Dec 14; Vol. 14 (675), pp. eabp9159. Date of Electronic Publication: 2022 Dec 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.abp9159 |
