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Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.

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Title: Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.
Authors: Gansane A; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso. agansane.cnrfp@fasonet.bf., Lingani M; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Ouagadougou, Burkina Faso., Yeka A; Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda., Nahum A; Centre de Recherches Entomologique de Cotonou (CREC), Cotonou, Benin., Bouyou-Akotet M; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine - Université des Sciences de la Santé, Libreville, Gabon., Mombo-Ngoma G; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany., Kaguthi G; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya., Barceló C; Medicines for Malaria Venture, Geneva, Switzerland., Laurijssens B; BEL Pharm Consulting, Chambonas, France., Cantalloube C; Sanofi Research and Development, Chilly Mazarin, France., Macintyre F; Medicines for Malaria Venture, Geneva, Switzerland., Djeriou E; Sanofi Research and Development, Chilly Mazarin, France., Jessel A; Sanofi Research and Development, Bridgewater, NJ, USA., Bejuit R; Sanofi Research and Development, Chilly Mazarin, France., Demarest H; Medicines for Malaria Venture, Geneva, Switzerland., Marrast AC; Medicines for Malaria Venture, Geneva, Switzerland., Debe S; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso., Tinto H; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Ouagadougou, Burkina Faso., Kibuuka A; Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda., Nahum D; Centre de Recherches Entomologique de Cotonou (CREC), Cotonou, Benin., Mawili-Mboumba DP; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine - Université des Sciences de la Santé, Libreville, Gabon., Zoleko-Manego R; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany., Mugenya I; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya., Olewe F; Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya.; Centre for Research in Therapeutic Sciences (CREATES), Strathmore University, Nairobi, Kenya., Duparc S; Medicines for Malaria Venture, Geneva, Switzerland., Ogutu B; Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya.; Centre for Research in Therapeutic Sciences (CREATES), Strathmore University, Nairobi, Kenya.
Source: Malaria journal [Malar J] 2023 Jan 03; Vol. 22 (1), pp. 2. Date of Electronic Publication: 2023 Jan 03.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Randomized, open-label, phase 2a study to evaluate the contribution of artefenomel to the clinical and parasiticidal activity of artefenomel plus ferroquine in African patients with uncomplicated Plasmodium falciparum malaria.
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  Data: <searchLink fieldCode="AU" term="%22Gansane+A%22">Gansane A</searchLink>; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso. agansane.cnrfp@fasonet.bf.<br /><searchLink fieldCode="AU" term="%22Lingani+M%22">Lingani M</searchLink>; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Yeka+A%22">Yeka A</searchLink>; Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Nahum+A%22">Nahum A</searchLink>; Centre de Recherches Entomologique de Cotonou (CREC), Cotonou, Benin.<br /><searchLink fieldCode="AU" term="%22Bouyou-Akotet+M%22">Bouyou-Akotet M</searchLink>; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine - Université des Sciences de la Santé, Libreville, Gabon.<br /><searchLink fieldCode="AU" term="%22Mombo-Ngoma+G%22">Mombo-Ngoma G</searchLink>; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kaguthi+G%22">Kaguthi G</searchLink>; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Barceló+C%22">Barceló C</searchLink>; Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laurijssens+B%22">Laurijssens B</searchLink>; BEL Pharm Consulting, Chambonas, France.<br /><searchLink fieldCode="AU" term="%22Cantalloube+C%22">Cantalloube C</searchLink>; Sanofi Research and Development, Chilly Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Macintyre+F%22">Macintyre F</searchLink>; Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Djeriou+E%22">Djeriou E</searchLink>; Sanofi Research and Development, Chilly Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Jessel+A%22">Jessel A</searchLink>; Sanofi Research and Development, Bridgewater, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Bejuit+R%22">Bejuit R</searchLink>; Sanofi Research and Development, Chilly Mazarin, France.<br /><searchLink fieldCode="AU" term="%22Demarest+H%22">Demarest H</searchLink>; Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Marrast+AC%22">Marrast AC</searchLink>; Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Debe+S%22">Debe S</searchLink>; Centre National de Recherche et de Formation sur le Paludisme (CNRFP), 01 BP 220801 BP 2208, Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Tinto+H%22">Tinto H</searchLink>; Institut de Recherche en Science de la Santé - Unité de Recherche Clinique de Nanoro (IRSS-URCN), Ouagadougou, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Kibuuka+A%22">Kibuuka A</searchLink>; Infectious Diseases Research Collaboration (IDRC), Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Nahum+D%22">Nahum D</searchLink>; Centre de Recherches Entomologique de Cotonou (CREC), Cotonou, Benin.<br /><searchLink fieldCode="AU" term="%22Mawili-Mboumba+DP%22">Mawili-Mboumba DP</searchLink>; Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine - Université des Sciences de la Santé, Libreville, Gabon.<br /><searchLink fieldCode="AU" term="%22Zoleko-Manego+R%22">Zoleko-Manego R</searchLink>; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, and University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mugenya+I%22">Mugenya I</searchLink>; Kenya Medical Research Institute-Centre for Respiratory Diseases Research (KEMRI-CRDR), Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Olewe+F%22">Olewe F</searchLink>; Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya.; Centre for Research in Therapeutic Sciences (CREATES), Strathmore University, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Duparc+S%22">Duparc S</searchLink>; Medicines for Malaria Venture, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ogutu+B%22">Ogutu B</searchLink>; Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya.; Centre for Research in Therapeutic Sciences (CREATES), Strathmore University, Nairobi, Kenya.
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  Data: <searchLink fieldCode="JN" term="%22101139802%22">Malaria journal</searchLink> [Malar J] 2023 Jan 03; Vol. 22 (1), pp. 2. <i>Date of Electronic Publication: </i>2023 Jan 03.
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  Data: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article
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