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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.

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Title: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.
Authors: Alejo S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Palacios BE; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Venkata PP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., He Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Li W; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Johnson JD; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Jayamohan S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Clarke K; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zou Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Lv Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Weldon K; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Lai Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Ye Z; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Chen Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Gilbert AR; Department of Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Suzuki T; The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan., Tekmal RR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zhao W; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Zheng S; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas, 78229, USA., Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Hematology & Oncology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.
Source: Neuro-oncology [Neuro Oncol] 2023 Jul 06; Vol. 25 (7), pp. 1249-1261.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.
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R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Jayamohan+S%22">Jayamohan S</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Pratap+UP%22">Pratap UP</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+K%22">Clarke K</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Zou+Y%22">Zou Y</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Lv+Y%22">Lv Y</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Weldon+K%22">Weldon K</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Viswanadhapalli+S%22">Viswanadhapalli S</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Lai+Z%22">Lai Z</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Ye+Z%22">Ye Z</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Gilbert+AR%22">Gilbert AR</searchLink>; Department of Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Suzuki+T%22">Suzuki T</searchLink>; The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tekmal+RR%22">Tekmal RR</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Population Health Sciences, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Vadlamudi+RK%22">Vadlamudi RK</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+AJ%22">Brenner AJ</searchLink>; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Department of Hematology & Oncology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Sareddy+GR%22">Sareddy GR</searchLink>; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, Texas, 78229, USA.
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