Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.

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Title: Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
Authors: Brooks L; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Dolton M; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Langenhorst J; Pharmetheus AB, Uppsala, Sweden., Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Lien YTK; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Malhi V; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Li C; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Perez-Moreno P; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA., Bond J; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA., Chen YC; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Yu J; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Source: Clinical and translational science [Clin Transl Sci] 2023 May; Vol. 16 (5), pp. 823-834. Date of Electronic Publication: 2023 Feb 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1752-8062
DOI:10.1111/cts.13491