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Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.

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Title: Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
Authors: Brooks L; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Dolton M; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Langenhorst J; Pharmetheus AB, Uppsala, Sweden., Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Lien YTK; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Malhi V; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Li C; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Perez-Moreno P; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA., Bond J; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA., Chen YC; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA., Yu J; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Source: Clinical and translational science [Clin Transl Sci] 2023 May; Vol. 16 (5), pp. 823-834. Date of Electronic Publication: 2023 Feb 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
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  Data: <searchLink fieldCode="AU" term="%22Brooks+L%22">Brooks L</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Dolton+M%22">Dolton M</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Langenhorst+J%22">Langenhorst J</searchLink>; Pharmetheus AB, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Yoshida+K%22">Yoshida K</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Lien+YTK%22">Lien YTK</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Malhi+V%22">Malhi V</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Perez-Moreno+P%22">Perez-Moreno P</searchLink>; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Bond+J%22">Bond J</searchLink>; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
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              Text: 2023 May
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