Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen.

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Title: Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen.
Authors: Bender AM; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA., Valentine MS; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA., Bauer JA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA., Days E; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee, USA., Lindsley CW; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA., Merryman WD; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Source: Assay and drug development technologies [Assay Drug Dev Technol] 2023 Apr; Vol. 21 (3), pp. 89-96. Date of Electronic Publication: 2023 Mar 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101151468 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8127 (Electronic) Linking ISSN: 1540658X NLM ISO Abbreviation: Assay Drug Dev Technol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1557-8127
DOI:10.1089/adt.2022.116