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Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.

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Title: Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome.
Authors: de Jesus AA; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Chen G; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Yang D; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Brdicka T; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Ruth NM; Medical University of South Carolina, Charleston, SC, USA., Bennin D; Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA., Cebecauerova D; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Malcova H; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Freeman H; Raigmore Hospital, Inverness, Scotland., Martin N; Royal Hospital for Children, Glasgow, Scotland., Svojgr K; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Passo MH; Medical University of South Carolina, Charleston, SC, USA., Bhuyan F; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Alehashemi S; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Rastegar AT; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Uss K; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kardava L; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Marrero B; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Duric I; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic., Omoyinmi E; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Peldova P; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Lee CR; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Kleiner DE; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hadigan CM; Clinical Center, National Institutes of Health, Bethesda, MD, USA., Hewitt SM; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Pittaluga S; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Carmona-Rivera C; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Calvo KR; Clinical Center, National Institutes of Health, Bethesda, MD, USA., Shah N; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Balascakova M; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Fink DL; Collaborative Clinical Research Branch/Neutrophil Monitoring Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA., Kotalova R; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Parackova Z; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Peterkova L; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Kuzilkova D; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Campr V; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Sramkova L; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Biancotto A; Sanofi Oncology, Vitry, France., Brooks SR; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Manes C; Yale University, New Haven, CT, USA., Meffre E; Yale University, New Haven, CT, USA., Harper RL; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kuehn H; Clinical Center, National Institutes of Health, Bethesda, MD, USA., Kaplan MJ; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Brogan P; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Rosenzweig SD; Clinical Center, National Institutes of Health, Bethesda, MD, USA., Merchant M; AstraZeneca Research Based Biopharmaceutical Company, Waltham, MA, USA., Deng Z; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA., Huttenlocher A; Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA., Moir SL; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kuhns DB; Collaborative Clinical Research Branch/Neutrophil Monitoring Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA., Boehm M; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Skvarova Kramarzova K; Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic., Goldbach-Mansky R; Translational Autoinflammatory Diseases Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. goldbacr@mail.nih.gov.
Source: Nature communications [Nat Commun] 2023 Mar 17; Vol. 14 (1), pp. 1502. Date of Electronic Publication: 2023 Mar 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-023-36941-y