Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.
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| Title: | Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity. |
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| Authors: | Chenoweth AM; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia., Esparon S; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia., Wines BD; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia., Schuurman J; Genmab, Utrecht, The Netherlands., Labrijn AF; Genmab, Utrecht, The Netherlands., Hogarth PM; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia. |
| Source: | Immunology and cell biology [Immunol Cell Biol] 2023 Aug; Vol. 101 (7), pp. 657-662. Date of Electronic Publication: 2023 Apr 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Wiley Country of Publication: United States NLM ID: 8706300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1711 (Electronic) Linking ISSN: 08189641 NLM ISO Abbreviation: Immunol Cell Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1440-1711 |
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| DOI: | 10.1111/imcb.12646 |
