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Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.

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Title: Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.
Authors: Chenoweth AM; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia., Esparon S; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia., Wines BD; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia., Schuurman J; Genmab, Utrecht, The Netherlands., Labrijn AF; Genmab, Utrecht, The Netherlands., Hogarth PM; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.
Source: Immunology and cell biology [Immunol Cell Biol] 2023 Aug; Vol. 101 (7), pp. 657-662. Date of Electronic Publication: 2023 Apr 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8706300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1711 (Electronic) Linking ISSN: 08189641 NLM ISO Abbreviation: Immunol Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.
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  Data: <searchLink fieldCode="AU" term="%22Chenoweth+AM%22">Chenoweth AM</searchLink>; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Esparon+S%22">Esparon S</searchLink>; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wines+BD%22">Wines BD</searchLink>; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schuurman+J%22">Schuurman J</searchLink>; Genmab, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Labrijn+AF%22">Labrijn AF</searchLink>; Genmab, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hogarth+PM%22">Hogarth PM</searchLink>; Immune Therapies Group, Burnet Institute, Melbourne, VIC, Australia.; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.
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  Data: <searchLink fieldCode="JN" term="%228706300%22">Immunology and cell biology</searchLink> [Immunol Cell Biol] 2023 Aug; Vol. 101 (7), pp. 657-662. <i>Date of Electronic Publication: </i>2023 Apr 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8706300 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1440-1711 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208189641%22">08189641 </searchLink><i>NLM ISO Abbreviation: </i>Immunol Cell Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1111/imcb.12646
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      – Code: eng
        Text: English
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      – TitleFull: Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.
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              Text: 2023 Aug
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