Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex.
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| Title: | Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. |
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| Authors: | Shirai T; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Nakai A; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Ando E; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Fujimoto J; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan., Leach S; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Arimori T; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan., Higo D; Thermo Fisher Scientific K.K., Yokohama, Kanagawa, Japan., van Eerden FJ; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Tulyeu J; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Liu YC; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan., Okuzaki D; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Murayama MA; Department of Animal Models for Human Diseases, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka, Japan., Miyata H; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Nunomura K; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Lin B; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Tani A; Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Laboratory of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan., Ikawa M; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan.; Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan., Wing JB; Laboratory of Human Single Cell Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Standley DM; Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan., Takagi J; Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan., Suzuki K; Laboratory of Immune Response Dynamics, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.; Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.; Department of Immune Response Dynamics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.; Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan. |
| Source: | Science immunology [Sci Immunol] 2023 Mar 31; Vol. 8 (81), pp. eadc9324. Date of Electronic Publication: 2023 Mar 31. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.adc9324 |
